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Every single child who desires of becoming a cop at some point has the idea of a uniformed individual chasing a nasty guy within the streets. Our meta-analysis confirmed no compelling evidence that antioxidant supplements forestall the progression of atherosclerosis. Of 6 no-PTCA trials using antioxidant nutritional vitamins in nontransplant patients, four relatively massive trials discovered both neutral or presumably dangerous results on atherosclerosis progression ( 21 , 23 , 24 , 26 ); 1 additional trial showed that antioxidants attenuated the protective effect of simvastatin-niacin on the development of atherosclerosis when utilized in combination ( 20 ). All these trials were placebo managed, double-blind, and randomized, which are considered characteristics of high-quality trials in customary high quality scores ( 40 ). Although the methods used to guage the progression of atherosclerosis had been heterogeneous, related methods did detect a benefit on atherosclerosis development in trials of statins ( forty one ). It’s thus unlikely that a substantial benefit of antioxidants would have been missed in our analysis.

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